- From: Alan Cantwell
- Date: February 23, 2008 2:46:58 PM PST
- To: Greg Blaney
- Cc: Trevor Marshall
- Subject: Re: "Acne bacteria" (P.acnes) repeatedly
found in prostate cancer!! More proof of "cancer bacteria"!!
-
- To Greg Blaney, MD:
-
- Thanks for notifying me regarding this important paper
published in the Journal of Clinical Microbiology in Nov, 2007......more
proof that "cancer bacteria" are involved in cancer -- and particularly in
prostate cancer -- now if only we could get pathologists to see these
bacteria in acid-fast stained sections of prostate ca -- as noted by me in
my partner's tissue sections taken from his prostate cancer when his
prostate gland was removed in 2004 - and pictured below in the paper
published in the Journal of Independent Medical Research (www.joimr.org)
in 2004.
-
- As you note -- from abstracts you attached below, this
is NOT the first time Propioniobacterium acnes has been associated with
prostate cancer......it amazes me that this research is largely ignored by
urologists (and also by the media) -- like Helicobacter pyloris in stomach
ulcers was ignored for decades by physicians.
-
- With prostate cancer being an older man's worst
nightmare -- one would expect greater interest in this!
-
- Best regards,
- ALAN CANTWELL, MD
-
-
- On Feb 23, 2008, at 9:10 AM, Greg Blaney wrote:
-
- 1: J Clin Microbiol. 2007 Nov;45(11):3721-8. Epub 2007
Sep 19. Links
- Direct visualization of Propionibacterium acnes in
prostate tissue by multicolor fluorescent in situ hybridization assay.
-
- Alexeyev OA, Marklund I, Shannon B, Golovleva I,
Olsson J, Andersson C, Eriksson I, Cohen R, Elgh F.
- Department of Pathology, Umeå University, S-90185,
Umeå, Sweden. oleg.alexeyev@medbio.umu.se
-
- Prostate tissues from patients with prostate cancer
and benign prostatic hyperplasia (BPH) frequently contain histological
inflammation, and a proportion of these patients show evidence of
Propionibacterium acnes infection in the prostate gland. We developed a
multicolor fluorescent in situ hybridization (FISH) assay targeting P.
acnes 23S rRNA along with a 14-kb region of the P. acnes genome. This
assay was used to analyze prostate tissues from patients with prostate
cancer and BPH. P. acnes infection of the prostate gland was demonstrated
in prostatic tissue in 5 of 10 randomly selected prostate cancer patients.
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- FISH analysis and confocal laser microscopy imaging
revealed intracellular localization and stromal biofilm-like aggregates as
common forms of P. acnes infection in prostate tissues from both prostate
cancer and BPH patients. A sequential analysis of prostate tissue from
individual patients suggested that P. acnes can persist for up to 6 years
in the prostate gland. These results indicate that P. acnes can establish
a persistent infection in the prostate gland. Further study is needed to
clarify the link between this bacterium and prostatic inflammation which
may contribute to the development of BPH and prostate cancer.
- PMID: 17881550 [PubMed - indexed for MEDLINE]
-
-
- -------------------
-
- http://www.joimr.org/phorum/read.php?f=2&i=57&t=57
-
- Acid-Fast Bacteria In-Vivo in Prostate Cancer and the
Connection between Prostate Cancer, Other Cancers, and the Kaposi's
Sarcoma Virus
-
-
- Author: Alan R Cantwell, Jr., M.D.
- Los Angeles, California,
- contact email: alancantwell@sbc global.net
-
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- Paper Type: Review
-
- Please cite as: Cantwell AR Jr. Acid-Fast Bacteria
In-Vivo in Prostate Cancer and the Connection between Prostate Cancer,
Other Cancers, and the Kaposi's Sarcoma Virus. JOIMR 2004;2(3):1
- Published: 28 May 2004
- (C) 2004, by Alan Cantwell, Jr. M.D.
-
- Abstract
-
- Bacteria in the form of previously described "cancer
microbes" were identified in a Fite (acid-fast)-stained histopathologic
tissue section from a case of prostate adenocarcinoma in a 68 year- old,
HIV-negative Italian-American man with a concomitant history of a solitary
skin lesion of classic Kaposi's sarcoma. The pleomorphic bacteria observed
in vivo are consistent with so-called cancer-associated bacteria
previously described in breast cancer, Kaposi's sarcoma, and other forms
of cancer, by various investigators over the past century. The proposed
microbiology of cancer is discussed, as well as the new finding of the
Kaposi's sarcoma virus (human herpes virus-8) in the blood of up to 40% of
patients with prostate cancer. Further studies of acid-fast bacteria in
vivo and the KS virus in prostate cancer are sorely needed to further
determine the possible role of these infectious agents in this common
cancer of men.
-
-
- 1: J Urol. 2000 Oct;164(4):1221-8.
- Related Articles, Links
-
- Bacterial dna sequences in prostate tissue from
patients with prostate cancer and chronic prostatitis.
-
- Krieger JN, Riley DE, Vesella RL, Miner DC, Ross SO,
Lange PH.
-
- Department of Urology, University of Washington,
School of Medicine, Seattle, Washington, USA.
-
- PURPOSE: Although bacterial genetic material has been
detected in prostate tissue from patients with various disorders, the
prevalence of these organisms is unknown. We tested the hypothesis that
bacterial detection rates differ between patients with prostate cancer and
those with the chronic prostatitis/pelvic pain syndrome. MATERIALS AND
METHODS: Sterile prostate biopsies were obtained during radical retropubic
prostatectomy from 107 patients with prostate cancer and using a perineal
approach from 170 with the chronic prostatitis/pelvic pain syndrome.
Numerous controls were also evaluated. Bacterial ribosomal encoding DNA
(165 rDNA) sequences were detected using a polymerase chain reaction
assay. Selected positives were cloned, sequenced and compared with DNA
databases. RESULTS: Bacterial DNA sequences were detected in 21 (19. 6%)
of 107 patients with prostate cancer compared to 79 (46.4%) of 170 with
chronic prostatitis (p <0.0001). These bacteria included urogenital
pathogens, other described microorganisms and bacteria not reported
previously. CONCLUSIONS: Bacterial DNA sequences may be identified in
prostate tissue from many patients. Bacterial detection rates in prostate
tissue appear to differ among populations, with higher rates among
patients with the chronic prostatitis/pelvic pain syndrome than among
those with prostate cancer. Future studies of the role of various bacteria
in the prostate may provide insight into the pathophysiology of prostate
disease.
-
- 1: J Urol. 2005 Jun;173(6):1969-74.
- Related Articles, Links
-
- Propionibacterium acnes associated with inflammation
in radical prostatectomy specimens: a possible link to cancer evolution?
-
- Cohen RJ, Shannon BA, McNeal JE, Shannon T, Garrett KL.
-
- Uropath Pty Ltd, Perth, Western Australia. ronnie@uropath.com.au
-
- PURPOSE: Inflammation is commonly observed in the
prostate gland and has been implicated in the development of prostate
cancer. The etiology of prostatic inflammation is unknown. However, the
involvement of a carcinogenic infectious agent has been suggested.
MATERIALS AND METHODS: Prostatic tissue from 34 consecutive patients with
prostate cancer was cultured to detect the presence of bacterial agents.
Prostatic inflammation was assessed by histological examination of
wholemount tissue sections. RESULTS: The predominant microorganism
detected was Propionibacterium acnes, found in 35% of prostate samples. A
significantly higher degree of prostatic inflammation was observed in
cases culture positive for P. acnes (p =0.007). P. acnes was separated
into 3 groups based on cell surface properties, phenotype and genetic
grouping. All skin control isolates were classified as group 1 whereas
most prostatic isolates were classified as groups 2 and 3. CONCLUSIONS: P.
acnes has been isolated from prostatic tissues in men who underwent
radical prostatectomy for localized cancer and has been shown to be
positively associated with prostatic inflammation. This inflammation may
then be linked to the evolution of carcinoma. Furthermore, organisms
infecting these patients with prostate cancer differ genetically and
phenotypically from the commonly identified cutaneous P. acnes isolates,
suggesting that specific subtypes may be involved in development of
prostatic inflammation.
-
-
- 1: Future Oncol. 2006 Apr;2(2):225-32. Links
- Links between Propionibacterium acnes and prostate
cancer.
-
- Shannon BA, Garrett KL, Cohen RJ.
- Tissugen Pty Ltd, Perth, Western Australia.
- Incidental foci of prostate cancer are found at
autopsy in 30% of men in their third decade, and by their eighth decade
more than 75% have histological evidence of cancer. This unprecedented
cancer prevalence points to a ubiquitous causative agent or perhaps an
interaction between multiple common carcinogenic cofactors. We propose
that one of these carcinogens is Propionibacterium acnes. Several
characteristics of prostate cancer suggest the involvement of an
infectious agent and we provide evidence that P. acnes is an excellent
candidate. We have cultured P. acnes from a substantial proportion of
prostate glands containing cancer and shown a significant positive
association with prostatic inflammation. P. acnes is well suited to cause
persistent, low-grade infection involving a marked inflammatory response
and the P. acnes subtypes most frequently associated with prostate cancer
become highly prevalent in the urinary tract of males following puberty.
- PMID: 16563091 [PubMed - indexed for MEDLINE]
-
-
- 1: Res Microbiol. 2007 May;158(4):386-92. Epub 2007
Feb 21. Links
- Biofilm formation by Propionibacterium acnes is
associated with increased resistance to antimicrobial agents and increased
production of putative virulence factors.
-
- Coenye T, Peeters E, Nelis HJ.
- Laboratorium voor Farmaceutische Microbiologie,
Universiteit Gent, Harelbekestraat 72, B-9000 Gent, Belgium. tom.coenye@ugent.be
- Propionibacterium acnes plays an important role in the
pathogenesis of acne vulgaris, a common disorder of the pilosebaceous
follicles. Recently, it was suggested that P. acnes cells residing within
the follicles grow as a biofilm. In the present study, we tested the
biofilm-forming ability of several P. acnes strains in a microtiter plate
model. We also evaluated the resistance of biofilm-grown P. acnes towards
antimicrobial agents commonly used in the treatment of acne and the
production of putative virulence factors. Our results indicate that P.
acnes can form biofilms in vitro. The results also show that sessile P.
acnes cells are more resistant to various commonly used antimicrobial
agents than planktonic cells. In addition, sessile cells produce more
extracellular lipases as well as significant amounts of the quorum-sensing
molecule autoinducer-2.
- PMID: 17399956 [PubMed - indexed for MEDLINE]
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